Ed (2.0 vs 12.0, respectively; P 0.001) [47]. Given the failure to achieve the primaryendpoint in the first study, another placebo-controlled study (n = 88) was conducted [48]. In this third study, icatibant 30 mg significantly reduced the median time to cutaneous or abdominal attack symptom relief (50 reduction from baseline in severity, assessed by a three-symptom [skin swelling, skin pain,
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